Synthesis of Sulfomucopolysaccharides in Thyroidectomized Rats
نویسنده
چکیده
The thyroid glands of rats were made non-functional by a single dose of iodine-131 on the 1st day after birth or by surgical removal on the 28th day. The incorporation of sulfate-sulfur into the sulfomucopolysaccharides of skeletons and pelts was found to be significantly depressed by thyroidectomy. Daily supplements of 5 or 10 gamma of L-thyroxine, started on the 28th day, increased the uptake of sulfur-35, although it did not reach normal in the 2 weeks of treatment. Autoradiograms of sections of tibiae and pelts confirmed the analytical data. The findings suggest that the synthesis of sulfomucopolysaccharides is depressed in thyroidectomized rats.
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 105 شماره
صفحات -
تاریخ انتشار 1957